A significant negative correlation was observed between autoregulatory vasodilation and the diameter response to hypercapnia in arterioles. At the same time, the diameter response to hypercapnia in arterioles was significantly decreased to 1.9% ± 1.5%.
At 14 days after UCCAO, arterioles, capillaries, and venules were autoregulatorily dilated by 79.5% ± 19.7%, 57.2% ☓2.3%, and 32.0% ± 10.8%, respectively. Before UCCAO, vasodilation during hypercapnia was found primarily in arterioles (22.9% ± 3.5%). Cerebral blood flow and the vascular response to hypercapnia were decreased after UCCAO. Diameters of the cortical microvessels during normocapnia and hypercapnia were also measured by TPLSM.
#DMG TO S 2 SOMATOSENSORY WINDOWS#
Cerebral blood flow (CBF) during normocapnia and hypercapnia was measured by laser-Doppler flowmetry through cranial windows in awake C57/BL6 mice before and at 1,7, 14, and 28 days after unilateral common carotid artery occlusion (UCCAO). We evaluated whether the vascular response to hypercapnia could represent the cerebrovascular reserve. This study aimed to examine the cortical microvessel diameter response to hypercapnia in misery perfusion using two-photon laser scanning microscopy (TPLSM).
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